{UTF-8}
********************************************************
	.benzoesaeure dermal
********************************************************~
		Simulation: Peter Bützer
	|

anfluten=
	k3*Blut
	~	mg/Hour [0,?]
	~		|

aufnehmen=
	k2*Stratum corneum
	~	mg/Hour [0,?]
	~		|

Blut= INTEG (
	aufnehmen-anfluten-eliminieren,
		0)
	~	mg [0,?]
	~		|

eindringen=
	k1*galenische Formulierung
	~	mg/Hour [0,?]
	~		|

eliminieren=
	k4*Blut
	~	mg/Hour [0,?]
	~		|

galenische Formulierung= INTEG (
	-eindringen,
		1)
	~	mg [0,?]
	~		|

k1=
	0.184
	~	1/Hour [0,?]
	~	Riedel Silke, Vergleichende Untersuchungen zur dermalen Penetration und \
		Permeation in Diffusionszellen, Dissertation, Tierärztliche Hochschule \
		Hannover, 2003, S.33
	|

k2=
	2.88
	~	1/Hour [0,?]
	~	Riedel Silke, Vergleichende Untersuchungen zur dermalen Penetration und \
		Permeation in Diffusionszellen, Dissertation, Tierärztliche Hochschule \
		Hannover, 2003, S.33
	|

k3=
	0.014
	~	1/Hour [0,?]
	~	Riedel Silke, Vergleichende Untersuchungen zur dermalen Penetration und \
		Permeation in Diffusionszellen, Dissertation, Tierärztliche Hochschule \
		Hannover, 2003, S.33
	|

k4=
	0.592
	~	1/Hour [0,?]
	~	Riedel Silke, Vergleichende Untersuchungen zur dermalen Penetration und \
		Permeation in Diffusionszellen, Dissertation, Tierärztliche Hochschule \
		Hannover, 2003, S.33
	|

Stratum corneum= INTEG (
	anfluten+eindringen-aufnehmen,
		0)
	~	mg [0,?]
	~		|

********************************************************
	.Control
********************************************************~
		Simulation Control Parameters
	|

FINAL TIME  = 48
	~	Hour
	~	The final time for the simulation.
	|

INITIAL TIME  = 0
	~	Hour
	~	The initial time for the simulation.
	|

SAVEPER  = 
        TIME STEP 
	~	Hour [0,?]
	~	The frequency with which output is stored.
	|

TIME STEP  = 0.1
	~	Hour [0,?]
	~	The time step for the simulation.
	|

\\\---/// Sketch information - do not modify anything except names
V300  Do not put anything below this section - it will be ignored
*View 1
$192-192-192,0,Helvetica|12||0-0-0|0-0-0|0-0-255|-1--1--1|-1--1--1|120,120,100,0
10,1,galenische Formulierung,93,132,61,35,3,131,0,4,0,0,0,0,0-0-0,192-255-255,|12||0-0-0
10,2,Stratum corneum,314,135,52,35,3,131,0,4,0,0,0,0,0-0-0,255-192-128,|12||0-0-0
10,3,Blut,518,138,52,38,3,131,0,4,0,0,0,0,0-0-0,255-0-0,|12||0-0-0
1,4,6,2,4,0,0,22,0,0,0,-1--1--1,,1|(238,133)|
1,5,6,1,100,0,0,22,0,0,0,-1--1--1,,1|(178,133)|
11,6,172,208,133,6,8,34,3,0,0,1,0,0,0
10,7,eindringen,208,154,47,13,40,3,0,0,-1,0,0,0
1,8,10,3,4,0,0,22,0,0,0,-1--1--1,,1|(445,104)|
1,9,10,2,100,0,0,22,0,0,0,-1--1--1,,1|(389,104)|
11,10,284,419,104,6,8,34,3,0,0,1,0,0,0
10,11,aufnehmen,419,125,50,13,40,3,0,0,-1,0,0,0
1,12,14,2,4,0,0,22,0,0,0,-1--1--1,,1|(387,164)|
1,13,14,3,100,0,0,22,0,0,0,-1--1--1,,1|(443,164)|
11,14,220,415,164,6,8,34,3,0,0,1,0,0,0
10,15,anfluten,415,185,36,13,40,3,0,0,-1,0,0,0
12,16,48,701,134,10,8,0,3,0,0,-1,0,0,0
1,17,19,16,4,0,0,22,0,0,0,-1--1--1,,1|(666,136)|
1,18,19,3,100,0,0,22,0,0,0,-1--1--1,,1|(599,136)|
11,19,48,635,136,6,8,34,3,0,0,1,0,0,0
10,20,eliminieren,635,157,48,13,40,3,0,0,-1,0,0,0
10,21,k1,144,48,13,13,8,3,0,0,0,0,0,0
10,22,k2,361,48,13,13,8,3,0,0,0,0,0,0
10,23,k3,487,223,13,13,8,3,0,0,0,0,0,0
10,24,k4,577,52,13,13,8,3,0,0,0,0,0,0
1,25,21,6,1,0,0,0,0,64,0,-1--1--1,,1|(200,63)|
1,26,22,10,1,0,0,0,0,64,0,-1--1--1,,1|(418,53)|
1,27,23,14,1,0,0,0,0,64,0,-1--1--1,,1|(437,217)|
1,28,24,19,1,0,0,0,0,64,0,-1--1--1,,1|(623,63)|
1,29,1,6,1,0,0,0,0,64,0,-1--1--1,,1|(168,90)|
1,30,2,10,1,0,0,0,0,64,0,-1--1--1,,1|(380,77)|
1,31,3,14,1,0,0,0,0,64,0,-1--1--1,,1|(461,197)|
1,32,3,19,1,0,0,0,0,64,0,-1--1--1,,1|(590,94)|
12,33,919142,385,481,326,220,3,188,0,0,1,0,0,0
dermale_Aufnahme
///---\\\
:GRAPH dermale_Aufnahme
:TITLE dermale Aufnahme
:X-AXIS Time
:SCALE
:VAR Stratum corneum
:LINE-WIDTH 2
:VAR Blut
:LINE-WIDTH 2
:L<%^E!@
1:Current.vdf
9:Current
23:0
15:0,0,0,0,0,0
19:100,0
27:2,
34:0,
4:Time
5:Blut
24:0
25:47.9998
26:47.9998