{UTF-8}
********************************************************
	.enzymregulation hefe
********************************************************~
		Simulation: Peter Bützer
	|

E1=
	IF THEN ELSE(S1<=0.1, 0 , k11*S1-kr*P7)-IF THEN ELSE(P1S2<=0.1, 0 , k12*P1S2 )
	~	mmol/Hour [0,?]
	~	Geschwindigkeit, mit der das Enzym 1 die Hin- und die Rückreaktion \
		katalysiert
	|

k65=
	0.1
	~	1/Hour [0,1]
	~		|

k66=
	0.1
	~	1/Hour [0,1]
	~		|

E4=
	k44*P3S4-k54*P4S5
	~	mmol/Hour [0,?]
	~	Geschwindigkeit, mit der das Enzym 4 die Hin- und die Rückreaktion \
		katalysiert
	|

E5=
	k55*P4S5-k65*P5S6
	~	mmol/Hour [0,?]
	~	Geschwindigkeit, mit der das Enzym 5 die Hin- und die Rückreaktion \
		katalysiert
	|

E6=
	k66*P5S6-k76*P6S7
	~	mmol/Hour [0,?]
	~	Geschwindigkeit, mit der das Enzym 6 die Hin- und die Rückreaktion \
		katalysiert
	|

E7=
	k77*P6S7-k87*P7
	~	mmol/Hour [0,?]
	~	Geschwindigkeit, mit der das Enzym 7 die Hin- und die Rückreaktion \
		katalysiert
	|

k54=
	0.1
	~	1/Hour [0,1]
	~		|

k55=
	0.1
	~	1/Hour [0,1]
	~		|

P3S4= INTEG (
	E3-E4,
		0.001)
	~	mmol [0,200]
	~		|

P4S5= INTEG (
	E4-E5,
		0)
	~	mmol [0,200]
	~		|

P5S6= INTEG (
	E5-E6,
		0)
	~	mmol [0,?]
	~		|

P6S7= INTEG (
	E6-E7,
		0)
	~	mmol [0,?]
	~		|

k44=
	0.1
	~	1/Hour [0,1]
	~		|

P7= INTEG (
	E7,
		0)
	~	mmol [0,?]
	~		|

k76=
	0.1
	~	1/Hour [0,1]
	~		|

k77=
	0.1
	~	1/Hour [0,1]
	~		|

k87=
	0.14
	~	1/Hour [0,1]
	~		|

E2=
	k22*P1S2-k23*P2S3
	~	mmol/Hour
	~	Geschwindigkeit, mit der das Enzym 2 die Hin- und die Rückreaktion \
		katalysiert
	|

E3=
	k33*P2S3- k34*P3S4
	~	mmol/Hour
	~	Geschwindigkeit, mit der das Enzym 3 die Hin- und die Rückreaktion \
		katalysiert
	|

S1= INTEG (
	-E1,
		100)
	~	mmol [0,?]
	~		|

kr=
	2
	~	1/Hour [0,3]
	~		|

k11=
	0.3
	~	1/Hour [0,1]
	~		|

k12=
	0.1
	~	1/Hour [0,1]
	~		|

k22=
	0.2
	~	1/Hour [0,1]
	~		|

k23=
	0.15
	~	1/Hour [0,1]
	~		|

k33=
	0.1
	~	1/Hour [0,1]
	~		|

k34=
	0.1
	~	1/Hour [0,1]
	~		|

P1S2= INTEG (
	E1-E2,
		1)
	~	mmol [0,?]
	~		|

P2S3= INTEG (
	E2-E3,
		1)
	~	mmol [0,200]
	~		|

********************************************************
	.Control
********************************************************~
		Simulation Control Parameters
	|

FINAL TIME  = 130
	~	Hour
	~	The final time for the simulation.
	|

INITIAL TIME  = 0
	~	Hour
	~	The initial time for the simulation.
	|

SAVEPER  = 1
	~	Hour [0,?]
	~	The frequency with which output is stored.
	|

TIME STEP  = 0.1
	~	Hour [0,?]
	~	The time step for the simulation.
	|

\\\---/// Sketch information - do not modify anything except names
V300  Do not put anything below this section - it will be ignored
*View 1
$192-192-192,0,Times New Roman|12||0-0-0|0-0-0|0-0-255|-1--1--1|-1--1--1|120,120,100,0
10,1,S1,71,176,40,20,3,3,0,0,0,0,0,0
10,2,P1S2,227,179,40,20,3,3,0,0,0,0,0,0
10,3,P2S3,388,183,40,20,3,3,0,0,0,0,0,0
10,4,P3S4,548,181,40,20,3,3,0,0,0,0,0,0
1,5,7,2,4,0,0,22,0,0,0,-1--1--1,,1|(169,177)|
1,6,7,1,100,0,0,22,0,0,0,-1--1--1,,1|(125,177)|
11,7,380,145,177,6,8,34,3,0,0,1,0,0,0
10,8,E1,145,196,11,11,40,3,0,0,-1,0,0,0
1,9,11,3,4,0,0,22,0,0,0,-1--1--1,,1|(330,178)|
1,10,11,2,100,0,0,22,0,0,0,-1--1--1,,1|(284,178)|
11,11,140,307,178,6,8,34,3,0,0,1,0,0,0
10,12,E2,307,197,11,11,40,3,0,0,-1,0,0,0
1,13,15,4,4,0,0,22,0,0,0,-1--1--1,,1|(492,182)|
1,14,15,3,100,0,0,22,0,0,0,-1--1--1,,1|(446,182)|
11,15,588,470,182,6,8,34,3,0,0,1,0,0,0
10,16,E3,470,201,11,11,40,3,0,0,-1,0,0,0
10,17,k11,80,241,22,12,8,131,0,0,0,0,0,0
10,18,k12,206,225,19,15,8,131,0,0,0,0,0,0
10,19,k22,256,246,18,12,8,131,0,0,0,0,0,0
10,20,k23,369,220,18,10,8,131,0,0,0,0,0,0
10,21,k33,410,245,20,12,8,131,0,0,0,0,0,0
10,22,k34,533,227,22,12,8,131,0,0,0,0,0,0
1,23,17,8,1,0,0,0,0,64,0,-1--1--1,,1|(115,242)|
1,24,18,8,1,0,0,0,0,64,0,-1--1--1,,1|(163,220)|
1,25,19,12,1,0,0,0,0,64,0,-1--1--1,,1|(294,245)|
1,26,20,12,1,0,0,0,0,64,0,-1--1--1,,1|(327,225)|
1,27,21,16,1,0,0,0,0,64,0,-1--1--1,,1|(456,241)|
1,28,22,16,1,0,0,0,0,64,0,-1--1--1,,1|(492,222)|
1,29,1,7,1,0,0,0,0,64,0,-1--1--1,,1|(106,140)|
1,30,2,7,1,0,0,0,0,64,0,-1--1--1,,1|(189,142)|
1,31,2,11,1,0,0,0,0,64,0,-1--1--1,,1|(271,137)|
1,32,3,11,1,0,0,0,0,64,0,-1--1--1,,1|(359,149)|
1,33,3,15,1,0,0,0,0,64,0,-1--1--1,,1|(423,145)|
1,34,4,15,1,0,0,0,0,64,0,-1--1--1,,1|(508,144)|
10,35,kr,112,78,9,11,8,3,0,0,0,0,0,0
1,36,35,7,1,0,0,0,0,64,0,-1--1--1,,1|(151,99)|
10,37,P4S5,705,184,40,20,3,3,0,0,0,0,0,0
1,38,40,37,4,0,0,22,0,0,0,-1--1--1,,1|(646,183)|
1,39,40,4,100,0,0,22,0,0,0,-1--1--1,,1|(602,183)|
11,40,412,622,183,6,8,34,3,0,0,1,0,0,0
10,41,E4,622,203,13,12,40,3,0,0,-1,0,0,0
10,42,k44,580,248,17,12,8,3,0,0,0,0,0,0
10,43,k54,689,234,17,12,8,3,0,0,0,0,0,0
1,44,43,41,1,0,0,0,0,64,0,-1--1--1,,1|(653,231)|
1,45,42,41,1,0,0,0,0,64,0,-1--1--1,,1|(620,247)|
1,46,4,40,1,0,0,0,0,64,0,-1--1--1,,1|(590,142)|
1,47,37,40,1,0,0,0,0,64,0,-1--1--1,,1|(666,143)|
10,48,P5S6,853,184,40,20,3,3,0,0,0,0,0,0
10,49,P6S7,1006,180,40,20,3,3,0,0,0,0,0,0
12,50,48,275,-15,10,8,0,3,0,0,-1,0,0,0
10,51,P7,1156,182,40,20,3,3,0,0,0,0,0,0
1,52,54,48,4,0,0,22,0,0,0,-1--1--1,,1|(799,184)|
1,53,54,37,100,0,0,22,0,0,0,-1--1--1,,1|(759,184)|
11,54,220,779,184,6,8,34,3,0,0,1,0,0,0
10,55,E5,779,204,13,12,40,3,0,0,-1,0,0,0
1,56,58,49,4,0,0,22,0,0,0,-1--1--1,,1|(950,182)|
1,57,58,48,100,0,0,22,0,0,0,-1--1--1,,1|(908,182)|
11,58,428,929,182,6,8,34,3,0,0,1,0,0,0
10,59,E6,929,202,13,12,40,3,0,0,-1,0,0,0
1,60,62,51,4,0,0,22,0,0,0,-1--1--1,,1|(1101,181)|
1,61,62,49,100,0,0,22,0,0,0,-1--1--1,,1|(1060,181)|
11,62,476,1081,181,6,8,34,3,0,0,1,0,0,0
10,63,E7,1081,201,13,12,40,3,0,0,-1,0,0,0
10,64,k55,730,250,17,12,8,3,0,0,0,0,0,0
10,65,k66,885,246,17,12,8,3,0,0,0,0,0,0
10,66,k77,1042,231,17,12,8,3,0,0,0,0,0,0
10,67,k65,828,240,17,12,8,3,0,0,0,0,0,0
10,68,k76,976,236,17,12,8,3,0,0,0,0,0,0
10,69,k87,1130,244,17,12,8,3,0,0,0,0,0,0
1,70,64,54,1,0,0,0,0,64,0,-1--1--1,,1|(778,241)|
1,71,67,55,1,0,0,0,0,64,0,-1--1--1,,1|(800,226)|
1,72,65,59,1,0,0,0,0,64,0,-1--1--1,,1|(910,223)|
1,73,68,59,1,0,0,0,0,64,0,-1--1--1,,1|(945,221)|
1,74,66,63,1,0,0,0,0,64,0,-1--1--1,,1|(1072,220)|
1,75,69,63,1,0,0,0,0,64,0,-1--1--1,,1|(1102,218)|
1,76,37,54,1,0,0,0,0,64,0,-1--1--1,,1|(749,153)|
1,77,48,54,1,0,0,0,0,64,0,-1--1--1,,1|(802,147)|
1,78,48,58,1,0,0,0,0,64,0,-1--1--1,,1|(901,152)|
1,79,49,58,1,0,0,0,0,64,0,-1--1--1,,1|(956,143)|
1,80,49,62,1,0,0,0,0,64,0,-1--1--1,,1|(1049,144)|
1,81,51,62,1,0,0,0,0,64,0,-1--1--1,,1|(1099,137)|
1,82,51,7,1,0,0,12,3,64,0,255-0-0,|12||0-0-0,1|(715,104)|
12,83,0,596,503,331,202,3,188,0,0,1,0,0,0
GRAPH
///---\\\
:GRAPH GRAPH
:TITLE GRAPH
:X-AXIS Time
:SCALE
:VAR P7
:Y-MIN 0
:LINE-WIDTH 2
:L<%^E!@
1:Current.vdf
9:Current
23:0
15:0,0,0,0,0,0
19:100,0
27:2,
34:0,
4:Time
5:P7
24:0
25:129.999
26:129.999