{UTF-8}
********************************************************
	.hormesis-bateman schwelle invers
********************************************************~
		Simulation: Peter Bützer
	|

Etot=
	E1-E2
	~	Dmnl
	~	Summe der beiden Effekte. Ein Effekt wird meist negativ genommen, also E1 \
		+ (-E2)
	|

E1=
	Em1*(Dosis)/(Kd1+Dosis)
	~	Dmnl [0,1]
	~	Effekt: gesamthaft
	|

E2=
	Em2*(Dosis-Schwelldosis)/(Kd2+Dosis-Schwelldosis)
	~	Dmnl [0,1]
	~	Effekt der reziproken Wirkung
	|

Em1=
	2
	~	Dmnl [0,?]
	~	maximaler Effekt
	|

Em2=
	1
	~	Dmnl [0,?]
	~	maximaler Effekt
	|

Schwelldosis=
	0
	~	mg [0,1]
	~	Schwelldosis für die Wirkung mit der grösseren Wirksamkeit
	|

Dosis= INTEG (
	resorbieren-eliminieren,
		0)
	~	mg [0,?]
	~	Dosis
	|

eliminieren=
	ke*Dosis
	~	mg/Hour [0,?]
	~	Geschwindigkeit mit der eliminiert wid
	|

"GI-Trakt"= INTEG (
	-resorbieren,
		10)
	~	mg [0,?]
	~	Menge im Gastrointestinal-Trakt
	|

ke=
	0.3
	~	1/Hour [0,?]
	~	Reaktionsgeschwindigkeitskonstante der Elimination
	|

Kd2=
	0.15
	~	mg [0,?]
	~	Dissoziationskonstante der "reziproken" Wirkung
	|

resorbieren=
	kr*"GI-Trakt"
	~	mg/Hour [0,?]
	~	Geschwindigkeit mit der resorbiert wid
	|

kr=
	2
	~	1/Hour [0,?]
	~	Reaktionsgeschwindigkeitskonstante der Resorption
	|

Kd1=
	6
	~	mg [0,10]
	~	Dissoziationskonstante der "normalen" Wirkung
	|

********************************************************
	.Control
********************************************************~
		Simulation Control Parameters
	|

FINAL TIME  = 48
	~	Hour
	~	The final time for the simulation.
	|

INITIAL TIME  = 0
	~	Hour
	~	The initial time for the simulation.
	|

SAVEPER  = 
        TIME STEP 
	~	Hour [0,?]
	~	The frequency with which output is stored.
	|

TIME STEP  = 0.01
	~	Hour [0,?]
	~	The time step for the simulation.
	|

\\\---/// Sketch information - do not modify anything except names
V300  Do not put anything below this section - it will be ignored
*View 1
$192-192-192,0,Times New Roman|12||0-0-0|0-0-0|0-0-255|-1--1--1|-1--1--1|120,120,100,0
10,1,E1,294,85,68,31,3,3,0,36,0,0,0,0,0-0-0,128-192-0,Arial|12||255-255-255
10,2,Kd1,116,106,20,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,3,2,1,1,0,0,0,0,64,0,-1--1--1,,1|(179,135)|
12,4,0,360,328,22,13,8,0,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
10,5,Dosis,290,219,58,23,3,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
12,6,0,843,278,321,232,3,188,0,0,1,0,0,0
Hormesis
10,7,E2,300,342,68,31,3,3,0,36,0,0,0,0,0-0-0,0-128-255,Arial|12||255-255-255
10,8,Kd2,135,349,20,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,9,8,7,1,0,0,0,0,64,0,-1--1--1,,1|(184,297)|
10,10,"GI-Trakt",63,221,48,21,3,131,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,11,13,5,4,0,0,22,0,0,0,-1--1--1,,1|(202,220)|
1,12,13,10,100,0,0,22,0,0,0,-1--1--1,,1|(136,220)|
11,13,364,167,220,6,8,34,3,0,0,1,0,0,0
10,14,resorbieren,167,241,52,13,40,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
12,15,48,478,220,10,8,0,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,16,18,15,4,0,0,22,0,0,0,-1--1--1,,1|(440,219)|
1,17,18,5,100,0,0,22,0,0,0,-1--1--1,,1|(374,219)|
11,18,48,407,219,6,8,34,3,0,0,1,0,0,0
10,19,eliminieren,407,240,48,13,40,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,20,10,13,1,0,0,0,0,64,0,-1--1--1,,1|(130,173)|
1,21,5,18,1,0,0,0,0,64,0,-1--1--1,,1|(363,186)|
10,22,kr,94,154,11,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
10,23,ke,355,157,13,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,24,22,13,1,0,0,0,0,64,0,-1--1--1,,1|(150,167)|
1,25,23,18,1,0,0,0,0,64,0,-1--1--1,,1|(387,176)|
1,26,5,7,1,0,0,0,0,64,0,-1--1--1,,1|(341,270)|
1,27,5,1,1,0,0,0,0,64,0,-1--1--1,,1|(324,155)|
10,28,Schwelldosis,73,301,59,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,29,28,7,1,0,0,0,0,64,0,-1--1--1,,1|(202,268)|
10,30,Em1,99,36,22,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
10,31,Em2,99,381,22,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,32,30,1,1,0,0,0,0,64,0,-1--1--1,,1|(174,40)|
1,33,31,7,1,0,0,0,0,64,0,-1--1--1,,1|(172,382)|
10,34,Etot,436,84,57,32,8,131,0,36,0,0,0,0,0-0-0,255-192-0,Arial|0||0-0-0
1,35,1,34,1,0,0,0,0,64,0,-1--1--1,,1|(351,39)|
1,36,7,34,1,0,0,0,0,64,0,-1--1--1,,1|(434,215)|
///---\\\
:GRAPH Hormesis
:TITLE Hormesis
:X-AXIS Time
:X-DIV 5
:Y-DIV 4
:SCALE
:VAR Etot|Erel
:UNITS Schaden-Nutzen
:Y-MIN -1
:Y-MAX 1
:LINE-WIDTH 2
:L<%^E!@
1:Current.vdf
9:Current
23:0
15:0,0,0,0,0,0
19:100,0
27:2,
34:0,
4:Time
5:Etot
24:0
25:47.998
26:47.998