{UTF-8}
********************************************************
	.Hormesis-Dosis-Wirkung Aspirin2
********************************************************~
		Simulation: Peter Bützer
	|

Em2=
	0.5
	~	Dmnl [0,?]
	~	maximaler Effekt
	|

E1=
	Em1*(Dosis)/(Kd1+Dosis)-E2
	~	Dmnl [0,1]
	~	Effekt: gesamthaft
	|

E2=
	Em2*(Dosis)/(Kd2+Dosis)
	~	Dmnl [0,1]
	~	Effekt der reziproken Wirkung
	|

Em1=
	0.5
	~	Dmnl [0,?]
	~	maximaler Effekt
	|

Dosis=
	10^logD-1
	~	Dmnl [0,?]
	~	Dosiszunahme für die Dosisachse der Funktion
	|

Kd2=
	1
	~	Dmnl [0,?]
	~	Dissoziationskonstante der "reziproken" Wirkung
	|

Kd1=
	100
	~	Dmnl [0,?]
	~	Dissoziationskonstante der "normalen" Wirkung
	|

logD= INTEG (
	Zunahme,
		0)
	~	Dmnl [0,?]
	~	log Dosiszunahme als Zeitfunktion
	|

Zunahme=
	1*1
	~	1/Second [1,1]
	~	logarithmischer Anstieg der Dosiszunahme
	|

********************************************************
	.Control
********************************************************~
		Simulation Control Parameters
	|

FINAL TIME  = 3
	~	Second
	~	The final time for the simulation.
	|

INITIAL TIME  = 0
	~	Second
	~	The initial time for the simulation.
	|

SAVEPER  = 
        TIME STEP
	~	Second [0,?]
	~	The frequency with which output is stored.
	|

TIME STEP  = 0.001
	~	Second [0,?]
	~	The time step for the simulation.
	|

\\\---/// Sketch information - do not modify anything except names
V300  Do not put anything below this section - it will be ignored
*View 1
$192-192-192,0,Times New Roman|12||0-0-0|0-0-0|0-0-255|-1--1--1|-1--1--1|120,120,100,0
12,1,48,99,221,10,8,0,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,2,3,1,100,0,0,22,0,0,0,-1--1--1,,1|(132,222)|
11,3,48,162,222,6,8,34,3,0,0,1,0,0,0
10,4,Zunahme,162,243,42,13,40,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
10,5,E1,294,85,68,31,3,3,0,36,0,0,0,0,0-0-0,128-192-0,Arial|12||255-255-255
10,6,Kd1,122,108,20,15,8,131,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,7,6,5,1,0,0,0,0,64,0,-1--1--1,,1|(179,135)|
10,8,Dosis,387,246,27,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,9,8,5,1,0,0,0,0,64,0,-1--1--1,,1|(374,178)|
12,10,0,360,328,23,13,8,0,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
10,11,logD,268,222,58,23,3,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,12,3,11,4,0,0,22,0,0,0,-1--1--1,,1|(189,222)|
1,13,11,8,1,0,0,0,0,64,0,-1--1--1,,1|(309,186)|
12,14,13109120,799,299,321,232,3,188,0,0,1,0,0,0
Hormesis
10,15,E2,300,342,68,31,3,3,0,36,0,0,0,0,0-0-0,0-128-255,Arial|12||255-255-255
10,16,Kd2,132,333,23,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,17,16,15,1,0,0,0,0,64,0,-1--1--1,,1|(195,297)|
1,18,15,5,1,0,0,0,0,64,0,-1--1--1,,1|(343,200)|
1,19,8,15,1,0,0,0,0,64,0,-1--1--1,,1|(359,297)|
10,20,Em1,106,33,22,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
10,21,Em2,104,397,22,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,22,20,5,0,0,0,0,0,64,0,-1--1--1,,1|(170,50)|
1,23,21,15,0,0,0,0,0,64,0,-1--1--1,,1|(172,377)|
///---\\\
:GRAPH Hormesis
:TITLE Hormesis
:X-AXIS logD
:X-LABEL log (Dosis)
:X-DIV 5
:Y-DIV 4
:SCALE
:VAR E1|.
:UNITS Schaden-Nutzen
:Y-MIN -1
:Y-MAX 1
:LINE-WIDTH 4
:L<%^E!@
1:Current.vdf
9:Current
23:0
15:0,0,0,0,0,0
19:100,0
27:2,
34:0,
4:Time
5:E1
24:0
25:2.99996
26:2.99996