{UTF-8}
********************************************************
	.Indigotin
********************************************************~
		Simulation: Peter Bützer                                          \
		Eighteenth Report of the Joint FAO/WHO Expert Committee on Food Additives, \
		Wld Hlth Org. techn. Rep.Ser., 1974, No. 557.     FAO Nutrition Meetings \
		Report Series, 1974, No. 54. INDIGOTINE
	|

ausscheiden=
	ka*Niere
	~	Percent/Hour [0,?]
	~		|

Blut= INTEG (
	resorbieren+unfiltriert-metabolisieren-filtrieren,
		0)
	~	Percent [0,?]
	~		|

Faeces= INTEG (
	passieren,
		0)
	~	Percent [0,?]
	~		|

filtrieren=
	kf*Blut
	~	Percent/Hour [0,?]
	~		|

Galle= INTEG (
	metabolisieren,
		0)
	~	Percent [0,?]
	~	After intravenous injection of 35S-labelled dye in the rats, 63% of the \
		radioactivity appeared in the urine in six hours and 10% in the bile.
	|

GI= INTEG (
	-passieren-resorbieren,
		100)
	~	Percent [0,?]
	~		|

HWZg=
	9.576
	~	Hour [0,?]
	~	After intravenous injection of S-35-labelled dye in the rats, 63% of the \
		radioactivity appeared in the urine in six hours and 10% in the bile. HWZ= \
		ln(2)*t*ln(a0/at)=ln(2)*6*ln(100/10)
	|

HWZr=
	0.5
	~	Hour
	~	Aufnahme etwa im üblichen Rahmen.
	|

ka=
	0.5
	~	1/Hour [0,4]
	~	The filterable fraction is about 15% while 75% of the colour is excreted \
		by the tubules.
	|

kf=
	0.3
	~	1/Hour [0,?]
	~	Anpassung, so dass Die Verteilung zwischen Galle und Urin stimmt. After \
		intravenous injection of S-35-labelled dye in the rats, 63% of the \
		radioactivity appeared in the urine in six hours and 10% in the bile. HWZ= \
		ln(2)*t*ln(a0/at)=ln(2)*6*ln(100/63)=0.35
	|

km=
	ln(2)/HWZg
	~	1/Hour [0,?]
	~		|

kp=
	kr*4
	~	1/Hour
	~	Faeces contained 60-80% of the oral dose. The faecal content was due to \
		lack of absorption, not biliary excretion (Lethco & Webb, 1966) -> daher \
		Faktor 4.
	|

kr=
	ln(2)/HWZr
	~	1/Hour
	~		|

ku=
	0.1
	~	1/Hour [0,?]
	~	The filterable fraction is about 15% while 75% of the colour is excreted \
		by the tubules.
	|

metabolisieren=
	km*Blut
	~	Percent/Hour [0,?]
	~		|

Niere= INTEG (
	-ausscheiden-unfiltriert+filtrieren,
		0)
	~	Percent [0,?]
	~		|

passieren=
	kp*GI
	~	Percent/Hour [0,?]
	~		|

resorbieren=
	kr*GI
	~	Percent/Hour [0,?]
	~		|

unfiltriert=
	ku*Niere
	~	Percent/Hour [0,?]
	~		|

Urin= INTEG (
	ausscheiden,
		0)
	~	Percent [0,?]
	~	After intravenous injection of 35S-labelled dye in the rats, 63% of the \
		radioactivity appeared in the urine in six hours and 10% in the bile.
	|

********************************************************
	.Control
********************************************************~
		Simulation Control Parameters
	|

FINAL TIME  = 72
	~	Hour
	~	The final time for the simulation.
	|

INITIAL TIME  = 0
	~	Hour
	~	The initial time for the simulation.
	|

SAVEPER  = 
        TIME STEP 
	~	Hour [0,?]
	~	The frequency with which output is stored.
	|

TIME STEP  = 0.1
	~	Hour [0,?]
	~	The time step for the simulation.
	|

\\\---/// Sketch information - do not modify anything except names
V300  Do not put anything below this section - it will be ignored
*View 1
$192-192-192,0,Arial|12||0-0-0|0-0-0|0-0-255|-1--1--1|-1--1--1|120,120,100,0
10,1,GI,218,251,40,20,3,3,0,0,0,0,0,0
10,2,Blut,390,252,40,20,3,3,0,4,0,0,0,0,0-0-0,255-0-0,|0||0-0-0
10,3,Niere,392,376,40,20,3,3,0,4,0,0,0,0,0-0-0,128-192-255,|0||0-0-0
1,4,6,2,4,0,0,22,0,0,0,-1--1--1,,1|(330,251)|
1,5,6,1,100,0,0,22,0,0,0,-1--1--1,,1|(278,251)|
11,6,0,304,251,6,8,34,3,0,0,1,0,0,0
10,7,resorbieren,304,272,52,13,40,3,0,0,-1,0,0,0
1,12,14,2,4,0,0,22,0,0,0,-1--1--1,,1|(420,288)|
1,13,14,3,100,0,0,22,0,0,0,-1--1--1,,1|(420,336)|
11,14,0,420,310,8,6,33,3,0,0,4,0,0,0
10,15,unfiltriert,468,310,40,13,40,3,0,0,-1,0,0,0
1,17,19,3,4,0,0,22,0,0,0,-1--1--1,,1|(366,340)|
1,18,19,2,100,0,0,22,0,0,0,-1--1--1,,1|(366,292)|
11,19,0,366,319,8,6,33,3,0,0,2,0,0,0
10,20,filtrieren,321,319,37,13,40,3,0,0,-1,0,0,0
10,22,Urin,618,373,40,20,3,3,0,4,0,0,0,0,0-0-0,255-255-128,|0||0-0-0
10,23,Faeces,220,377,40,20,3,3,0,4,0,0,0,0,0-0-0,128-64-0,|0||0-0-0
1,25,27,23,4,0,0,22,0,0,0,-1--1--1,,1|(218,338)|
1,26,27,1,100,0,0,22,0,0,0,-1--1--1,,1|(218,289)|
11,27,0,218,314,8,6,33,3,0,0,2,0,0,0
10,28,passieren,165,314,45,13,40,3,0,0,-1,0,0,0
1,30,32,22,4,0,0,22,0,0,0,-1--1--1,,1|(544,372)|
1,31,32,3,100,0,0,22,0,0,0,-1--1--1,,1|(465,372)|
11,32,0,504,372,6,8,34,3,0,0,1,0,0,0
10,33,ausscheiden,504,393,56,13,40,3,0,0,-1,0,0,0
1,35,1,27,1,0,0,0,0,64,0,-1--1--1,,1|(185,290)|
1,36,1,6,1,0,0,0,0,64,0,-1--1--1,,1|(268,211)|
1,37,2,19,1,0,0,0,0,64,0,-1--1--1,,1|(340,295)|
1,38,3,14,1,0,0,0,0,64,0,-1--1--1,,1|(454,336)|
1,40,3,32,1,0,0,0,0,64,0,-1--1--1,,1|(468,343)|
10,41,kr,244,179,11,13,8,3,0,0,0,0,0,0
10,42,kp,125,282,13,13,8,3,0,0,0,0,0,0
10,43,kf,309,372,10,13,8,3,0,0,0,0,0,0
10,44,ku,524,311,12,13,8,3,0,0,0,0,0,0
10,45,ka,427,429,13,13,8,3,0,0,0,0,0,0
1,46,45,32,1,0,0,0,0,64,0,-1--1--1,,1|(483,414)|
1,48,42,27,1,0,0,0,0,64,0,-1--1--1,,1|(177,290)|
1,49,41,6,1,0,0,0,0,64,0,-1--1--1,,1|(286,202)|
1,50,44,14,1,0,0,0,0,64,0,-1--1--1,,1|(489,294)|
1,51,43,19,1,0,0,0,0,64,0,-1--1--1,,1|(326,338)|
10,52,Galle,618,253,40,20,3,3,0,4,0,0,0,0,0-0-0,192-255-192,|0||0-0-0
1,54,56,52,4,0,0,22,0,0,0,-1--1--1,,1|(545,252)|
1,55,56,2,100,0,0,22,0,0,0,-1--1--1,,1|(465,252)|
11,56,0,506,252,6,8,34,3,0,0,1,0,0,0
10,57,metabolisieren,506,273,66,13,40,131,0,0,-1,0,0,0
10,58,km,440,176,15,13,8,3,0,0,0,0,0,0
1,59,2,56,1,0,0,0,0,64,0,-1--1--1,,1|(450,207)|
1,60,58,56,1,0,0,0,0,64,0,-1--1--1,,1|(486,196)|
10,62,HWZg,330,138,30,13,8,3,0,0,0,0,0,0
1,63,62,58,1,0,0,0,0,64,0,-1--1--1,,1|(390,127)|
10,64,HWZr,135,152,28,13,8,3,0,0,0,0,0,0
1,65,64,41,1,0,0,0,0,64,0,-1--1--1,,1|(189,141)|
1,66,41,42,1,0,0,0,0,64,0,-1--1--1,,1|(159,201)|
12,67,0,957,277,256,185,3,188,0,0,1,0,0,0
Ausscheidung
///---\\\
:GRAPH Ausscheidung
:TITLE Ausscheidung
:X-AXIS Time
:SCALE
:VAR Urin
:LINE-WIDTH 2
:VAR Galle
:LINE-WIDTH 2
:L<%^E!@
1:Current.vdf
9:Current
22:$,Dollar,Dollars,$s
22:Hour,Hours
22:Month,Months
22:Person,People,Persons
22:Unit,Units
22:Week,Weeks
22:Year,Years
22:Day,Days
23:0
15:0,0,0,0,0,0
19:100,0
27:2,
34:0,
4:Time
5:Niere
24:0
25:71.9995
26:71.9995