{UTF-8}
********************************************************
	.michaelis menten komplett
********************************************************~
		Simulation: Peter Bützer
	|

Ef= INTEG (
	RGe2-RGe1,
		0.01)
	~	mmol/l [0,?]
	~	Freies Enzym, das mit S reagieren kann
	|

Eg= INTEG (
	RGe1-RGe2,
		0)
	~	mmol/l [0,?]
	~	Gebundenes Enzym
	|

ES= INTEG (
	RG1-RG2-RG3,
		0)
	~	mmol/l [0,?]
	~	Enzym-Substrat-Komplex
	|

S= INTEG (
	+RG2-RG1,
		1)
	~	mmol/l [0,?]
	~	Substrat
	|

RGe1=
	k1*S*Ef
	~	mmol/(Second*l) [0,?]
	~		|

RGe2=
	(k2+k3)*Eg
	~	mmol/(l*Second) [0,?]
	~	ES zerfällt zurück zu S (Gleichgewicht) und zu (S+P); die erste Reaktion \
		hat k2, die zweite k3. Da beide Reaktionen gleichzeitig ablaufen, \
		zerfällt ES (also auch das gebundene Eg) mit (k2+k3)*Eg. E wird auch \
		gelich rasch frei, wie P.
	|

RG2=
	k2*ES
	~	mmol/(l*Second) [0,?]
	~		|

RG1=
	k1*Ef*S
	~	mmol/(l*Second) [0,?]
	~		|

k1=
	0.5
	~	l/(Second*mmol) [0,5]
	~		|

k2=
	0.001
	~	1/Second [0,?]
	~		|

k3=
	3
	~	1/Second [0,3]
	~		|

Km=
	k2/k1
	~	mmol/l [0,?]
	~	Michaelis-Menten-Konstante; Dissoziationskonstante
	|

P= INTEG (
	RG3,
		0)
	~	mmol/l [0,?]
	~	Produkt
	|

RG3=
	k3*ES
	~	mmol/(Second*l)
	~		|

********************************************************
	.Control
********************************************************~
		Simulation Control Parameters
	|

FINAL TIME  = 300
	~	Second
	~	The final time for the simulation.
	|

INITIAL TIME  = 0
	~	Second
	~	The initial time for the simulation.
	|

SAVEPER  = 
        TIME STEP 
	~	Second [0,?]
	~	The frequency with which output is stored.
	|

TIME STEP  = 0.1
	~	Second [0,?]
	~	The time step for the simulation.
	|

\\\---/// Sketch information - do not modify anything except names
V300  Do not put anything below this section - it will be ignored
*View 1
$192-192-192,0,Times New Roman|12||0-0-0|0-0-0|0-0-255|-1--1--1|-1--1--1|120,120,100,0
10,1,S,231,236,42,24,3,131,0,0,0,0,0,0
10,2,ES,408,237,40,23,3,131,0,0,0,0,0,0
10,3,P,572,235,40,20,3,3,0,0,0,0,0,0
10,4,Ef,233,325,40,23,3,131,0,0,0,0,0,0
10,5,Eg,410,325,40,23,3,131,0,0,0,0,0,0
1,6,8,2,4,0,0,22,0,0,0,-1--1--1,,1|(335,253)|
1,7,8,1,100,0,0,22,2,0,0,-1--1--1,|12||0-0-0,1|(281,253)|
11,8,220,296,253,6,8,34,3,0,0,1,0,0,0
10,9,RG1,296,273,21,12,40,3,0,0,-1,0,0,0
1,10,12,3,4,0,0,22,0,0,0,-1--1--1,,1|(514,234)|
1,11,12,2,100,0,0,22,0,0,0,-1--1--1,,1|(466,234)|
11,12,252,490,234,6,8,34,3,0,0,1,0,0,0
10,13,RG3,490,254,21,12,40,3,0,0,-1,0,0,0
1,14,16,5,4,0,0,22,0,0,0,-1--1--1,,1|(336,341)|
1,15,16,4,100,0,0,22,2,0,0,-1--1--1,|12||0-0-0,1|(282,341)|
11,16,284,297,341,6,8,34,3,0,0,1,0,0,0
10,17,RGe1,297,361,25,12,40,3,0,0,-1,0,0,0
10,18,k1,217,166,12,12,8,3,0,0,0,0,0,0
10,19,k2,413,163,12,12,8,3,0,0,0,0,0,0
10,20,k3,482,169,12,12,8,3,0,0,0,0,0,0
1,21,1,8,1,0,0,0,0,64,0,-1--1--1,,1|(255,274)|
1,22,2,13,1,0,0,0,0,64,0,-1--1--1,,1|(472,272)|
1,23,20,12,1,0,0,0,0,64,0,-1--1--1,,1|(493,202)|
1,24,4,8,1,0,0,0,0,64,0,-1--1--1,,1|(286,287)|
1,25,1,16,1,0,0,0,0,64,0,-1--1--1,,1|(279,300)|
1,26,18,16,1,0,0,0,0,64,0,-1--1--1,,1|(313,243)|
1,27,4,16,1,0,0,0,0,64,0,-1--1--1,,1|(260,367)|
10,28,Km,327,159,16,12,8,3,0,0,0,0,0,0
1,29,18,28,1,0,0,0,0,64,0,-1--1--1,,1|(282,188)|
1,30,19,28,1,0,0,0,0,64,0,-1--1--1,,1|(345,182)|
1,31,33,1,4,0,0,22,0,0,0,-1--1--1,,1|(303,219)|
1,32,33,2,100,0,0,22,0,0,0,-1--1--1,,1|(357,219)|
11,33,396,340,219,6,8,34,3,0,0,1,0,0,0
10,34,RG2,340,239,21,12,40,3,0,0,-1,0,0,0
1,35,18,8,1,0,0,0,0,64,0,-1--1--1,,1|(263,190)|
1,36,38,4,4,0,0,22,0,0,0,-1--1--1,,1|(304,306)|
1,37,38,5,100,0,0,22,0,0,0,-1--1--1,,1|(359,306)|
11,38,268,342,306,6,8,34,3,0,0,1,0,0,0
10,39,RGe2,342,326,25,12,40,3,0,0,-1,0,0,0
1,40,20,38,1,0,0,0,0,64,0,-1--1--1,,1|(372,288)|
1,41,5,38,1,0,0,0,0,64,0,-1--1--1,,1|(377,284)|
1,42,19,38,1,0,0,0,0,64,0,-1--1--1,,1|(381,272)|
1,43,2,33,1,0,0,0,0,64,0,-1--1--1,,1|(362,199)|
1,44,19,33,1,0,0,0,0,64,0,-1--1--1,,1|(369,206)|
///---\\\
:GRAPH Produktbildung
:TITLE Produktbildung
:X-AXIS S
:SCALE
:VAR RG3
:L<%^E!@
9:Current
23:0
15:0,0,0,0,0,0
19:100,0
27:2,
34:0,
5:Ef
24:0
25:0
26:0