{UTF-8}
********************************************************
	.saeure-basen-haushalt
********************************************************~
		Simulation: Peter Bützer
	|

Einheitenkorr=
	0.001*1
	~	mmol [0.001,0.001]
	~	Korrektur der Einheiten vom pH-Wert, weil der Logarithmus nur von einer \
		dimensionslosen Zahl berechnet werden kann. Zusätzlich Umrechnung von \
		mmol in mol, da der pH-Wert sich auf [H30+] in mol/l bezieht.
	|

He= INTEG (
	RG21-RG22,
		3.98e-005)
	~	mmol [2.51e-005,6.31e-005]
	~	Protonen (H3O+) extracellulär pH=7.4 -> 3.98*10-8 mol/l = 3.98*10-5 mmol/l
	|

Hi= INTEG (
	RG22-RG21,
		Startwert H)
	~	mmol [6.31e-005,0.000126]
	~	Protonen (H3O+) intracellulär
	|

K=
	1e+007
	~	Dmnl [0,1e+008]
	~	Gleichgewichtskonstante
	|

Kaliummenge=
	10
	~	mmol [0,200]
	~		|

zuführen=
	kz*Nahrung
	~	mmol/Second [0,0.1]
	~	Zufuhr von Kaliumionen
	|

Nahrung= INTEG (
	-zuführen,
		Kaliummenge)
	~	mmol [0,?]
	~	Aufnahme aus der Nahrung über den GI-Trakt, Molmasse Kalium: 39.102 g/mol \
		- 1 mmol = 39 mg, gefährlich sind Werte über 6 mmol/l Blut = 234 mg/l
	|

kr=
	kv/K
	~	1/(Second*mmol) [0,1e-018]
	~		|

pH i=
	-ln(Hi*Einheitenkorr)/2.3
	~	Dmnl [0,14]
	~	2.3: Korrektur vom natürlichen zum Zehnerlogarithmus
	|

RG11=
	kv*Ke*Hi
	~	mmol/Second [0,?]
	~	Reaktionsgeschwindigkeit Kalium: extracellulär-intracellulär
	|

RG22=
	kr*Ki*He
	~	mmol/Second
	~	Reaktionsgeschwindigkeit Protonen: extracellulär-intracellulär
	|

pH e=
	-ln(He*Einheitenkorr)/2.3
	~	Dmnl [0,14]
	~	2.3: Korrektur vom natürlichen zum Zehnerlogarithmus
	|

kz=
	0.0017
	~	1/Second [0,20]
	~	Reaktionsgeschwindigkeitskonstante: Halbwertszeit für die Aufnahme 600 s \
		= 5 Minuten -> kz=0.0017
	|

Ke= INTEG (
	+RG12-RG11+zuführen,
		4)
	~	mmol [0,7]
	~	Normbereich im Serum: 3.6–5.4 mmol/l, Kalium extracellulär: 4 mmol/l
	|

Startwert H=
	8.91e-005
	~	mmol [6.31e-005,0.000126]
	~	pH=7.05 -> 8.91e-5 mmol/l
	|

kv=
	1e-005
	~	1/(mmol*Second) [0,0.0001]
	~		|

Ki= INTEG (
	RG11-RG12,
		150)
	~	mmol [130,170]
	~	intrazelluläre Kaliumkonzentration: ungefähr 150 mmol/l
	|

RG12=
	kr*Ki*He
	~	mmol/Second [0,?]
	~	Reaktionsgeschwindigkeit Kalium: intracellulär-extracellulär
	|

RG21=
	kv*Ke*Hi
	~	mmol/Second [0,?]
	~	Reaktionsgeschwindigkeit Protonen: intracellulär-extracellulär
	|

********************************************************
	.Control
********************************************************~
		Simulation Control Parameters
	|

FINAL TIME  = 600
	~	Second
	~	The final time for the simulation.
	|

INITIAL TIME  = 0
	~	Second
	~	The initial time for the simulation.
	|

SAVEPER  = 
        TIME STEP 
	~	Second [0,?]
	~	The frequency with which output is stored.
	|

TIME STEP  = 1
	~	Second [0,?]
	~	The time step for the simulation.
	|

\\\---/// Sketch information - do not modify anything except names
V300  Do not put anything below this section - it will be ignored
*View 1
$192-192-192,0,Times New Roman|12||0-0-0|0-0-0|0-0-255|-1--1--1|-1--1--1|120,120,100,0
10,1,Ke,347,132,60,40,3,3,0,36,0,0,0,0,0-0-0,255-255-128,Arial|12||0-0-0
10,2,Hi,350,275,61,41,3,3,0,36,0,0,0,0,0-0-0,255-255-0,Arial|12||0-0-0
10,3,Ki,692,137,61,43,3,3,0,36,0,0,0,0,0-0-0,192-255-192,Arial|12||0-0-0
10,4,He,692,276,63,40,3,3,0,36,0,0,0,0,0-0-0,0-255-0,Arial|12||0-0-0
1,5,7,3,4,0,0,22,0,0,0,-1--1--1,,1|(566,107)|
1,6,7,1,100,0,0,22,0,0,0,-1--1--1,,1|(446,107)|
11,7,220,493,107,8,10,34,3,0,0,1,0,0,0
10,8,RG11,493,130,28,13,40,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,9,11,1,4,0,0,22,0,0,0,-1--1--1,,1|(464,156)|
1,10,11,3,100,0,0,22,0,0,0,-1--1--1,,1|(584,156)|
11,11,300,529,156,8,10,34,3,0,0,1,0,0,0
10,12,RG12,529,179,28,13,40,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,13,15,4,4,0,0,22,0,0,0,-1--1--1,,1|(566,244)|
1,14,15,2,100,0,0,22,0,0,0,-1--1--1,,1|(449,244)|
11,15,284,495,244,8,10,34,3,0,0,1,0,0,0
10,16,RG21,495,267,28,13,40,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,17,19,2,4,0,0,22,0,0,0,-1--1--1,,1|(471,299)|
1,18,19,4,100,0,0,22,0,0,0,-1--1--1,,1|(588,299)|
11,19,236,539,299,8,10,34,3,0,0,1,0,0,0
10,20,RG22,539,322,28,13,40,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,21,1,15,1,0,0,0,0,64,0,-1--1--1,,1|(412,197)|
1,22,3,11,1,0,0,0,0,64,0,-1--1--1,,1|(617,172)|
1,24,2,15,1,0,0,0,0,64,0,-1--1--1,,1|(437,230)|
1,25,1,7,1,0,0,0,0,64,0,-1--1--1,,1|(431,91)|
1,26,2,7,1,0,0,0,0,64,0,-1--1--1,,1|(464,170)|
1,27,4,11,1,0,0,0,0,64,0,-1--1--1,,1|(583,241)|
1,28,3,19,1,0,0,0,0,64,0,-1--1--1,,1|(576,217)|
10,29,kv,398,30,25,25,2,3,0,36,0,0,0,0,0-0-0,0-255-255,Arial|12||0-0-0
10,30,kr,642,375,25,25,2,3,0,36,0,0,0,0,0-0-0,255-192-128,Arial|12||0-0-0
1,31,29,7,1,0,0,0,0,64,0,-1--1--1,,1|(463,64)|
1,32,29,15,1,0,0,0,0,64,0,-1--1--1,,1|(458,194)|
1,33,30,19,1,0,0,0,0,64,0,-1--1--1,,1|(565,339)|
1,34,30,11,1,0,0,0,0,64,0,-1--1--1,,1|(532,233)|
10,35,Startwert H,191,275,53,13,8,131,0,32,0,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,37,39,1,4,0,0,22,0,0,0,-1--1--1,,1|(243,131)|
11,39,48,192,131,8,10,34,3,0,0,1,0,0,0
10,40,zuführen,192,154,39,13,40,131,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
10,42,kz,139,71,12,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,43,42,39,1,0,0,0,0,64,0,-1--1--1,,1|(174,89)|
1,67,35,2,0,0,0,0,0,64,1,-1--1--1,,1|(259,275)|
10,70,pH e,740,374,23,13,8,131,0,32,0,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,71,4,70,1,0,0,0,0,64,0,-1--1--1,,1|(697,337)|
1,73,4,19,1,0,0,0,0,64,0,-1--1--1,,1|(613,310)|
10,78,K,457,349,9,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,79,29,30,1,0,0,0,0,64,0,-1--1--1,,1|(507,201)|
1,80,78,30,1,0,0,0,0,64,0,-1--1--1,,1|(512,377)|
10,82,pH i,303,374,19,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,83,2,82,1,0,0,0,0,64,0,-1--1--1,,1|(338,331)|
12,84,0,898,636,299,198,3,188,0,32,1,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
pH
10,85,Einheitenkorr,511,431,59,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,86,85,82,1,0,0,0,0,64,0,-1--1--1,,1|(380,406)|
1,87,85,70,1,0,0,0,0,64,0,-1--1--1,,1|(634,424)|
10,89,Nahrung,74,136,53,38,3,131,0,32,0,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,90,39,89,100,0,0,22,0,0,0,-1--1--1,,1|(155,131)|
1,91,89,39,1,0,0,0,0,64,0,-1--1--1,,1|(122,90)|
10,92,Kaliummenge,76,198,64,18,8,131,0,32,0,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,93,92,89,0,0,0,0,0,64,1,-1--1--1,,1|(76,183)|
///---\\\
:GRAPH pH
:TITLE pH
:X-AXIS Time
:SCALE
:VAR pH e|extracellulär
:Y-MIN 7
:Y-MAX 7.5
:LINE-WIDTH 3
:VAR pH i|intracellulär
:LINE-WIDTH 3
:L<%^E!@
1:Current.vdf
9:Current
23:0
15:0,0,0,1,0,0
19:100,0
27:2,
34:0,
4:Time
5:K
24:0
25:600
26:600