{UTF-8}
********************************************************
	.saeure base natriumcitrat
********************************************************~
		Simulation Peter Bützer
	|

pH Urin=
	IF THEN ELSE(Urin>0,14-1/2*(8.81-LN(2.57*10^-8*0.1+Urin/0.1*Einheitenkorr)/LN(10)) ,\
		5.8 )
	~	Dmnl [0,14]
	~	pKb=8.81, bei pH=5.8 ist pOH=8.2 --> c=10^(pKb-2pOH) --> c= 2.57e-8
	|

Einheitenkorr=
	1*1
	~	1/mol [1,1]
	~	Logarithmen können nur von dimensionslosen Werten berechnet werden.
	|

pH Blut=
	14-1/2*(8.81-LN(3.98*10^-5+Blut/5*Einheitenkorr)/LN(10))
	~	Dmnl [0,14]
	~	pKb=8.81, bei pH 7.395 ist pOH=6.605 --> c=10^(pKb-2pOH) --> c= 3.98e-5
	|

Ausscheidung=
	ku*Urin
	~	mol/Hour [0,?]
	~	8 mal in 8 Stunden ausgeschieden
	|

ku=
	60
	~	1/Hour [50,100]
	~		|

Zufuhr= INTEG (
	-Ingestion,
		Dosis/294)
	~	mol
	~	0.0714 mol entspr. 21 Gramm --> 0.3 g/kg für eine Person mit 70 kg, 294.1 \
		g/mol; Molmasse von Natriumcitrat-Dihydrat
	|

Dosis=
	21
	~	mol [14,35,7]
	~		|

HWZr=
	9
	~	Hour [0,?]
	~	Abschätzung, Aufnahme im Dünndarm
	|

Urin= INTEG (
	Elimination-Ausscheidung,
		0)
	~	mol [0,?]
	~		|

kr=
	LN(2)/HWZr
	~	1/Hour
	~		|

Blut= INTEG (
	+Resorption-Elimination,
		0)
	~	mol [0,?]
	~		|

Elimination=
	ke*Blut
	~	mol/Hour [0,?]
	~		|

Ingestion=
	IF THEN ELSE(Zufuhr>0, ki , 0 )
	~	mol/Hour [0,?]
	~		|

ke=
	12
	~	1/Hour [10,100]
	~	Abschätzung: HWZ 3.5 Min
	|

ki=
	0.03
	~	mol/Hour [0,?]
	~	0.001 mol = 1 mmol = 300 mg ;0.001*60 --> 0.06 -->  ca. 300 mg/min; ca. \
		50% wird aufgenommen --> 0.03
	|

Resorption=
	kr*Verdauungstrakt
	~	mol/Hour [0,?]
	~		|

Verdauungstrakt= INTEG (
	Ingestion-Resorption,
		0)
	~	mol [0,?]
	~		|

********************************************************
	.Control
********************************************************~
		Simulation Control Parameters
	|

FINAL TIME  = 8
	~	Hour
	~	The final time for the simulation.
	|

INITIAL TIME  = 0
	~	Hour
	~	The initial time for the simulation.
	|

SAVEPER  = 0.5
	~	Hour [0,?]
	~	The frequency with which output is stored.
	|

TIME STEP  = 0.01
	~	Hour [0,?]
	~	The time step for the simulation.
	|

\\\---/// Sketch information - do not modify anything except names
V300  Do not put anything below this section - it will be ignored
*View 1
$192-192-192,0,Times New Roman|12||0-0-0|0-0-0|0-0-255|-1--1--1|-1--1--1|120,120,100,0
10,1,Zufuhr,86,114,40,20,3,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
10,2,Verdauungstrakt,306,114,74,23,3,131,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
10,3,Blut,545,116,40,20,3,3,0,38,0,0,0,0,0-0-0,255-0-0,Arial|12||255-255-255
10,4,Urin,742,115,40,20,3,3,0,36,0,0,0,0,0-0-0,255-192-0,Arial|12||0-0-0
1,5,7,2,4,0,0,22,0,0,0,-1--1--1,,1|(210,117)|
1,6,7,1,100,0,0,22,0,0,0,-1--1--1,,1|(151,117)|
11,7,172,182,117,6,8,34,3,0,0,1,0,0,0
10,8,Ingestion,182,138,42,13,40,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,10,12,3,4,0,0,22,0,0,0,-1--1--1,,1|(471,117)|
1,11,12,2,100,0,0,22,0,0,0,-1--1--1,,1|(403,117)|
11,12,48,432,117,6,8,34,3,0,0,1,0,0,0
10,13,Resorption,432,138,50,13,40,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,14,16,4,4,0,0,22,0,0,0,-1--1--1,,1|(674,116)|
1,15,16,3,100,0,0,22,0,0,0,-1--1--1,,1|(610,116)|
11,16,364,641,116,6,8,34,3,0,0,1,0,0,0
10,17,Elimination,641,137,49,13,40,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
10,18,ki,137,163,9,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
10,19,kr,371,172,11,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
10,20,ke,581,171,13,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,21,18,7,1,0,0,0,0,64,0,-1--1--1,,1|(179,164)|
1,22,19,13,1,0,0,0,0,64,0,-1--1--1,,1|(415,169)|
1,23,20,17,1,0,0,0,0,64,0,-1--1--1,,1|(627,166)|
1,24,2,13,1,0,0,0,0,64,0,-1--1--1,,1|(367,62)|
1,25,3,16,1,0,0,0,0,64,0,-1--1--1,,1|(590,64)|
1,26,1,7,1,0,0,0,0,64,0,-1--1--1,,1|(125,68)|
10,27,pH Blut,523,249,34,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,28,3,27,1,0,0,0,0,64,0,-1--1--1,,1|(492,196)|
10,29,pH Urin,711,246,34,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,30,4,29,1,0,0,0,0,64,0,-1--1--1,,1|(700,191)|
10,31,HWZr,297,199,28,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,32,31,19,1,0,0,0,0,64,0,-1--1--1,,1|(369,221)|
12,33,48,914,130,10,8,0,3,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,34,36,33,4,0,0,22,0,0,0,-1--1--1,,1|(878,132)|
1,35,36,4,100,0,0,22,0,0,0,-1--1--1,,1|(811,132)|
11,36,48,847,132,6,8,34,3,0,0,1,0,0,0
10,37,Ausscheidung,847,159,65,19,40,131,0,32,-1,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,38,4,36,1,0,0,0,0,64,0,-1--1--1,,1|(793,73)|
10,39,Dosis,65,42,27,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,40,39,1,0,0,0,0,0,0,1,-1--1--1,,1|(71,67)|
10,41,ku,773,189,12,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|12||0-0-0
1,42,41,37,1,0,0,0,0,64,0,-1--1--1,,1|(828,203)|
12,43,0,609,530,317,230,3,188,0,0,1,0,0,0
pH-Werte
10,44,Einheitenkorr,619,216,59,13,8,3,0,32,0,0,0,0,0-0-0,0-0-0,Arial|0||0-0-0
1,45,44,27,1,0,0,0,0,64,0,-1--1--1,,1|(532,217)|
1,46,44,29,1,0,0,0,0,64,0,-1--1--1,,1|(680,200)|
///---\\\
:GRAPH pH-Werte
:TITLE pH-Werte
:X-AXIS Time
:X-LABEL Zeit (Std)
:SCALE
:VAR pH Blut|pH Blut
:Y-MIN 7.35
:Y-MAX 7.8
:LINE-WIDTH 2
:SCALE
:VAR pH Urin|pH Urin
:Y-MIN 5
:Y-MAX 8.5
:LINE-WIDTH 2
:L<%^E!@
1:Current.vdf
9:Current
23:0
15:0,0,0,0,0,0
19:100,0
27:2,
34:0,
4:Time
5:Zufuhr
24:0
25:8.00009
26:8.00009